Publikation

Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis

Wissenschaftlicher Artikel/Review - 01.12.1994

Bereiche
PubMed

Zitation
Moradpour D, Altorfer J, Flury R, Greminger P, Meyenberger C, Jost R, Schmid M. Chlorpromazine-induced vanishing bile duct syndrome leading to biliary cirrhosis. Hepatology (Baltimore, Md.) 1994; 20:1437-41.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Hepatology (Baltimore, Md.) 1994; 20
Veröffentlichungsdatum
01.12.1994
ISSN (Druck)
0270-9139
Seiten
1437-41
Kurzbeschreibung/Zielsetzung

We describe a 33-yr-old pregnant woman in whom a primary biliary cirrhosis-like syndrome developed after 2 wk of chlorpromazine therapy. The clinical course was characterized by severe jaundice lasting 22 mo, intense pruritus, fever, steatorrhea, high alkaline phosphatase levels and hypercholesterolemia. Jaundice resolved with initiation of ursodeoxycholic acid therapy, but subclinical cholestasis and low-level inflammatory activity persisted and ultimately evolved into biliary cirrhosis. The pathological substrate of this severe and prolonged cholestatic reaction was found to be the vanishing bile duct syndrome with a marked transient pseudoxanthomatosis.