Publikation

EXAM: Ex-vivo allograft monitoring dashboard for the analysis of hypothermic machine perfusion data in deceased-donor kidney transplantation.

Wissenschaftlicher Artikel/Review - 18.12.2024

Bereiche
PubMed
DOI
Kontakt

Zitation
Schwab S, Steck H, Binet F, Elmer A, Ender W, Franscini N, Haidar F, Kuhn C, Sidler D, Storni F, Kruegel N, Immer F. EXAM: Ex-vivo allograft monitoring dashboard for the analysis of hypothermic machine perfusion data in deceased-donor kidney transplantation. PLOS Digit Health 2024; 3:e0000691.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
PLOS Digit Health 2024; 3
Veröffentlichungsdatum
18.12.2024
eISSN (Online)
2767-3170
Seiten
e0000691
Kurzbeschreibung/Zielsetzung

Deceased-donor kidney allografts are exposed to ischemic injury during ex vivo transport due to the lack of blood oxygen supply. Hypothermic machine perfusion (HMP) effectively reduces the risk of delayed graft function in kidney transplant recipients compared to standard cold storage. However, no free software implementation is available to analyze HMP data for state-of-the-art visualization and quality control. We developed the tool EXAM (ex-vivo allograft monitoring) as an interactive analytics dashboard. We wrote functions in the R programming language to read, process, and analyze HMP data from the LifePort kidney transporter (Organ Recovery Systems, USA). Time series for pressure, flow rate, organ resistance, and temperature are visualized, and relevant statistical indicators have been developed. We explain how data were processed, and indicators were calculated, and we present summary statistics for N = 255 kidney allografts receiving machine perfusion in Switzerland between 2020 and 2023. Median (interdecile range, IDR) of the main indicators were as follows: perfusion duration 5.18 hours (2.29-11.2), flow rate 110 ml/min (52.9-167), ice temperature 1.97°C (1.53-3.07), and perfusate temperature 6.68°C (5.58-8.36). We implemented the dashboard to identify issues, such as atypical perfusion parameters, high ice, or high perfusate temperature to inform transplant centers for quality assurance. In conclusion, EXAM is a free tool that statisticians and data scientists can quickly deploy to enable quality control at transplant organizations that use LifePort kidney transporters. An online viewer is available at https://data.swisstransplant.org/exam/.