Aneurysm wall cellularity affects healing after coil embolization: assessment in a rat saccular aneurysm model.

Publikation

Aneurysm wall cellularity affects healing after coil embolization: assessment in a rat saccular aneurysm model.

Wissenschaftlicher Artikel/Review - 23.12.2019

Nevzati Edin, Rey Jeannine, Coluccia Daniel, Grüter Basil Erwin, Wanderer Stefan, vonGunten Michael, Remonda Luca, Frosen Juhana, Widmer Hans Rudolf, Fandino Javier, Marbacher Serge

Zitation

Nevzati E, Rey J, Coluccia D, Grüter B, Wanderer S, vonGunten M, Remonda L, Frosen J, Widmer H, Fandino J, Marbacher S. Aneurysm wall cellularity affects healing after coil embolization: assessment in a rat saccular aneurysm model. J Neurointerv Surg 2019; 12:621-625.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Neurointerv Surg 2019; 12

Veröffentlichungsdatum

23.12.2019

eISSN (Online)

1759-8486

Seiten

621-625

Kurzbeschreibung/Zielsetzung

Despite significant technical advances, recanalization rates after endovascular therapy of ruptured intracranial aneurysms (IAs) remain a clinical challenge. A histopathological hallmark of ruptured human IA walls is mural cell loss. Mural smooth muscle cells (SMCs) are known to promote intraluminal healing in thrombosed experimental aneurysms. In this rat model we assess the natural history and healing process after coil embolization in SMC-rich and decellularized aneurysms.