Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis.

Publikation

Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis.

Wissenschaftlicher Artikel/Review - 11.03.2024

Wendebourg Maria Janina, Weigel Matthias, Weidensteiner Claudia, Sander Laura, Kesenheimer Eva, Naumann Nicole, Haas Tanja, Madoerin Philipp, Braun Nathalie, Neuwirth Christoph, Weber Markus, Jahn Kathleen, Kappos Ludwig, Granziera Cristina, Schweikert Kathi, Sinnreich Michael, Bieri Oliver, Schlaeger Regina

Zitation

Wendebourg M, Weigel M, Weidensteiner C, Sander L, Kesenheimer E, Naumann N, Haas T, Madoerin P, Braun N, Neuwirth C, Weber M, Jahn K, Kappos L, Granziera C, Schweikert K, Sinnreich M, Bieri O, Schlaeger R. Cervical and thoracic spinal cord gray matter atrophy is associated with disability in patients with amyotrophic lateral sclerosis. Eur J Neurol 2024:e16268.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Eur J Neurol 2024

Veröffentlichungsdatum

11.03.2024

eISSN (Online)

1468-1331

Seiten

e16268

Kurzbeschreibung/Zielsetzung

In amyotrophic lateral sclerosis (ALS), there is an unmet need for more precise patient characterization through quantitative, ideally operator-independent, assessments of disease extent and severity. Radially sampled averaged magnetization inversion recovery acquisitions (rAMIRA) magnetic resonance imaging enables gray matter (GM) and white matter (WM) area quantitation in the cervical and thoracic spinal cord (SC) with optimized contrast. We aimed to investigate rAMIRA-derived SC GM and SC WM areas and their association with clinical phenotype and disability in ALS.