Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer.

Publikation

Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer.

Wissenschaftlicher Artikel/Review - 26.12.2023

Vlajnic Tatjana, Muller David C, Ruiz Christian, Schönegg René, Seifert Hans-Helge, Thalmann George N, Zellweger Tobias, Le Magnen Clémentine, Rentsch Cyrill A, Bubendorf Lukas

Zitation

Vlajnic T, Muller D, Ruiz C, Schönegg R, Seifert H, Thalmann G, Zellweger T, Le Magnen C, Rentsch C, Bubendorf L. Exploring the intratumoral heterogeneity of DNA ploidy in prostate cancer. Cancer Rep (Hoboken) 2023:e1953.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Cancer Rep (Hoboken) 2023

Veröffentlichungsdatum

26.12.2023

eISSN (Online)

2573-8348

Seiten

e1953

Kurzbeschreibung/Zielsetzung

Prostate cancer is morphologically and molecularly heterogeneous. Genomic heterogeneity might be mirrored by variability in DNA ploidy. Aneuploidy is a hallmark of genomic instability and associated with tumor aggressiveness. Little attention has been paid to the biological significance of the diploid tumor cell population that often coexists with aneuploid populations. Here, we investigated the role of DNA ploidy in tumor heterogeneity and clonal evolution.