Publikation

Surgical site infections after kidney transplantation are independently associated with graft loss.

Wissenschaftlicher Artikel/Review - 30.11.2023

Bereiche
PubMed
DOI
Kontakt

Zitation
Schreiber P, Hoessly L, Boggian K, Neofytos D, Van Delden C, Egli A, Dickenmann M, Hirzel C, Manuel O, Koller M, Rossi S, Banz V, Schmied B, Gürke L, Matter M, de Rougemont O, Bonani M, Golshayan D, Schnyder A, Sidler D, Haidar F, Kuster S, Stampf S, Müller N, members of the Swiss Transplant Cohort Study (STCS). Surgical site infections after kidney transplantation are independently associated with graft loss. Am J Transplant 2023
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Am J Transplant 2023
Veröffentlichungsdatum
30.11.2023
eISSN (Online)
1600-6143
Kurzbeschreibung/Zielsetzung

Surgical site infections (SSIs) are common health care-associated infections. SSIs after kidney transplantation (K-Tx) can endanger patient and allograft survival. Multicenter studies on this early posttransplant complication are scarce. We analyzed consecutive adult K-Tx recipients enrolled in the Swiss Transplant Cohort Study who received a K-Tx between May 2008 and September 2020. All data were prospectively collected with the exception of the categorization of SSI which was performed retrospectively according to the Centers for Disease Control and Prevention criteria. A total of 58 out of 3059 (1.9%) K-Tx recipients were affected by SSIs. Deep incisional (15, 25.9%) and organ/space infections (34, 58.6%) predominated. In the majority of SSIs (52, 89.6%), bacteria were detected, most frequently Escherichia coli (15, 28.9%), Enterococcus spp. (14, 26.9%), and coagulase-negative staphylococci (13, 25.0%). A BMI ≥25 kg/m (multivariable OR 2.16, 95% CI 1.07-4.34, P = .023) and delayed graft function (multivariable OR 2.88, 95% CI 1.56-5.34, P = .001) were independent risk factors for SSI. In Cox proportional hazard models, SSI was independently associated with graft loss (multivariable HR 3.75, 95% CI 1.35-10.38, P = .011). In conclusion, SSI was a rare complication after K-Tx. BMI ≥25 kg/m and delayed graft function were independent risk factors. SSIs were independently associated with graft loss.