Publikation

Vitamin C Deficiency in Blood Samples of COVID-19 Patients.

Wissenschaftlicher Artikel/Review - 15.08.2022

Bereiche
PubMed
DOI
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Zitation
Sinnberg T, Lichtensteiger C, Hill-Mündel K, Leischner C, Niessner H, Busch C, Renner O, Wyss N, Flatz L, Lauer U, Hoelzle L, Nohr D, Burkard M, Marongiu L, Venturelli S. Vitamin C Deficiency in Blood Samples of COVID-19 Patients. Antioxidants (Basel) 2022; 11
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Antioxidants (Basel) 2022; 11
Veröffentlichungsdatum
15.08.2022
ISSN (Druck)
2076-3921
Kurzbeschreibung/Zielsetzung

Coronavirus disease 2019 (COVID-19) is the most notable pandemic of the modern era. A relationship between ascorbate (vitamin C) and COVID-19 severity is well known, whereas the role of other vitamins is less understood. The present study compared the blood levels of four vitamins in a cohort of COVID-19 patients with different severities and uninfected individuals. Serum concentrations of ascorbate, calcidiol, retinol, and α-tocopherol were measured in a cohort of 74 COVID-19 patients and 8 uninfected volunteers. The blood levels were statistically compared and additional co-morbidity factors were considered. COVID-19 patients had significantly lower plasma ascorbate levels than the controls (-value < 0.001), and further stratification revealed that the controls had higher levels than fatal, critical, and severe COVID-19 cases (-values < 0.001). However, no such trend was observed for calcidiol, retinol, or α-tocopherol (-value ≥ 0.093). Survival analysis showed that plasma ascorbate below 11.4 µM was associated with a lengthy hospitalization and a high risk of death. The results indicated that COVID-19 cases had depleted blood ascorbate associated with poor medical conditions, confirming the role of this vitamin in the outcome of COVID-19 infection.