Publikation

Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial.

Wissenschaftlicher Artikel/Review - 25.01.2023

Bereiche
PubMed
DOI
Kontakt

Zitation
Mohebbi N, Ritter A, Wiegand A, Graf N, Dahdal S, Sidler D, Arampatzis S, Hadaya K, Müller T, Wagner C, Wüthrich R. Sodium bicarbonate for kidney transplant recipients with metabolic acidosis in Switzerland: a multicentre, randomised, single-blind, placebo-controlled, phase 3 trial. Lancet 2023; 401:557-567.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Lancet 2023; 401
Veröffentlichungsdatum
25.01.2023
eISSN (Online)
1474-547X
Seiten
557-567
Kurzbeschreibung/Zielsetzung

Metabolic acidosis is common in kidney transplant recipients and is associated with declining graft function. Sodium bicarbonate treatment effectively corrects metabolic acidosis, but no prospective studies have examined its effect on graft function. Therefore, we aimed to test whether sodium bicarbonate treatment would preserve graft function and slow the progression of estimated glomerular filtration rate (GFR) decline in kidney transplant recipients.