Publikation

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.

Wissenschaftlicher Artikel/Review - 19.01.2023

Bereiche
PubMed
DOI
Kontakt

Zitation
Bakker M, Kanning J, Abraham G, Martinsen A, Winsvold B, Zwart J, Bourcier R, Sawada T, Koido M, Kamatani Y, Morel S, Amouyel P, Debette S, Bijlenga P, Berrandou T, Ganesh S, Bouatia-Naji N, Jones G, Bown M, Rinkel G, Veldink J, Ruigrok Y, Hostettler I. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity. Stroke 2023
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Stroke 2023
Veröffentlichungsdatum
19.01.2023
eISSN (Online)
1524-4628
Kurzbeschreibung/Zielsetzung

Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics.