Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.

Publikation

Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.

Wissenschaftlicher Artikel/Review - 19.01.2023

Bakker Mark K, Kanning Jos P, Abraham Gad, Martinsen Amy E, Winsvold Bendik S, Zwart John-Anker, Bourcier Romain, Sawada Tomonobu, Koido Masaru, Kamatani Yoichiro, Morel Sandrine, Amouyel Philippe, Debette Stephanie, Bijlenga Philippe, Berrandou Takiy, Ganesh Santhi K, Bouatia-Naji Nabila, Jones Gregory T, Bown Matthew, Rinkel Gabriel J E, Veldink Jan H, Ruigrok Ynte M, Hostettler Isabel

Zitation

Bakker M, Kanning J, Abraham G, Martinsen A, Winsvold B, Zwart J, Bourcier R, Sawada T, Koido M, Kamatani Y, Morel S, Amouyel P, Debette S, Bijlenga P, Berrandou T, Ganesh S, Bouatia-Naji N, Jones G, Bown M, Rinkel G, Veldink J, Ruigrok Y, Hostettler I. Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity. Stroke 2023

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Stroke 2023

Veröffentlichungsdatum

19.01.2023

eISSN (Online)

1524-4628

Kurzbeschreibung/Zielsetzung

Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its association with patient characteristics.