Optimized Treatment of Refractory Hypercholesterolemia in Patients With Atherosclerotic Cardiovascular Disease or Heterozygous Familial Hypercholesterolemia With Alirocumab (OPTIMIZE).

Publikation

Optimized Treatment of Refractory Hypercholesterolemia in Patients With Atherosclerotic Cardiovascular Disease or Heterozygous Familial Hypercholesterolemia With Alirocumab (OPTIMIZE).

Wissenschaftlicher Artikel/Review - 15.07.2022

Sudano Isabella, Mach François, Moccetti Tiziano, Burkard Thilo, Fahe Christian, Delabays Alain, Rickli Hans, Keller Pierre-Fréderic, Dopheide Jörn, Bodenmann Sereina, Fiolka Tom, Ehret Georg, Spirk David

Zitation

Sudano I, Mach F, Moccetti T, Burkard T, Fahe C, Delabays A, Rickli H, Keller P, Dopheide J, Bodenmann S, Fiolka T, Ehret G, Spirk D. Optimized Treatment of Refractory Hypercholesterolemia in Patients With Atherosclerotic Cardiovascular Disease or Heterozygous Familial Hypercholesterolemia With Alirocumab (OPTIMIZE). Front Cardiovasc Med 2022; 9:953040.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Front Cardiovasc Med 2022; 9

Veröffentlichungsdatum

15.07.2022

ISSN (Druck)

2297-055X

Seiten

953040

Kurzbeschreibung/Zielsetzung

Low-density lipoprotein cholesterol (LDL-C) is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). In confirmatory trials, proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab substantially lowered LDL-C and reduced cardiovascular morbidity and mortality. However, the routine clinical use of alirocumab in Switzerland has not yet been studied.