Publikation

Polymorphisms in MIR27A Associated with Early-Onset Toxicity in Fluoropyrimidine-Based Chemotherapy.

Wissenschaftlicher Artikel/Review - 05.02.2015

PubMed
DOI
Kontakt

Zitation
Amstutz U, Offer S, Sistonen J, Joerger M, Diasio R, Largiadèr C. Polymorphisms in MIR27A Associated with Early-Onset Toxicity in Fluoropyrimidine-Based Chemotherapy. Clin Cancer Res 2015; 21:2038-44.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Clin Cancer Res 2015; 21
Veröffentlichungsdatum
05.02.2015
eISSN (Online)
1557-3265
Seiten
2038-44
Kurzbeschreibung/Zielsetzung

The microRNA miR-27a was recently shown to directly regulate dihydropyrimidine dehydrogenase (DPD), the key enzyme in fluoropyrimidine catabolism. A common polymorphism (rs895819A>G) in the miR-27a genomic region (MIR27A) was associated with reduced DPD activity in healthy volunteers, but the clinical relevance of this effect is still unknown. Here, we assessed the association of MIR27A germline variants with early-onset fluoropyrimidine toxicity.