Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation.

Publikation

Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation.

Wissenschaftlicher Artikel/Review - 30.05.2022

Oliveri Franziska, Basler Michael, Rao Tata Nageswara, Fehling Hans Joerg, Groettrup Marcus

Zitation

Oliveri F, Basler M, Rao T, Fehling H, Groettrup M. Immunoproteasome Inhibition Reduces the T Helper 2 Response in Mouse Models of Allergic Airway Inflammation. Front Immunol 2022; 13:870720.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Front Immunol 2022; 13

Veröffentlichungsdatum

30.05.2022

eISSN (Online)

1664-3224

Seiten

870720

Kurzbeschreibung/Zielsetzung

Allergic asthma is a chronic disease and medical treatment often fails to fully control the disease in the long term, leading to a great need for new therapeutic approaches. Immunoproteasome inhibition impairs T helper cell function and is effective in many (auto-) inflammatory settings but its effect on allergic airway inflammation is unknown.