Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera.

Publikation

Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera.

Wissenschaftlicher Artikel/Review - 18.06.2017

Meyer Sara C, Steinmann Eva, Lehmann Thomas, Muesser Patricia, Passweg Jakob R, Skoda Radek C, Tsakiris Dimitrios A

Zitation

Meyer S, Steinmann E, Lehmann T, Muesser P, Passweg J, Skoda R, Tsakiris D. Anti-Platelet Factor 4/Heparin Antibody Formation Occurs Endogenously and at Unexpected High Frequency in Polycythemia Vera. Biomed Res Int 2017; 2017:9876819.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Biomed Res Int 2017; 2017

Veröffentlichungsdatum

18.06.2017

eISSN (Online)

2314-6141

Seiten

9876819

Kurzbeschreibung/Zielsetzung

Myeloproliferative neoplasms (MPN) encounter thromboses due to multiple known risk factors. Heparin-induced thrombocytopenia (HIT) is a thrombotic syndrome mediated by anti-platelet factor 4 (PF4)/heparin antibodies with undetermined significance for thrombosis in MPN. We hypothesized that anti-PF4/heparin Ab might occur in MPN and promote thrombosis.