Publikation

The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions.

Wissenschaftlicher Artikel/Review - 21.02.2022

Bereiche
PubMed
DOI
Kontakt

Zitation
Wuillemin N, Ballmer-Weber B, Schlapbach C, Jörg L, Yerly D. The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions. Front Allergy 2022; 3:804605.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Front Allergy 2022; 3
Veröffentlichungsdatum
21.02.2022
eISSN (Online)
2673-6101
Seiten
804605
Kurzbeschreibung/Zielsetzung

β-lactam antibiotics cause drug hypersensitivity reactions (DHR) with various clinical pictures from minor affections like maculopapular exanthema (MPE) and urticaria to severe cutaneous adverse reactions and anaphylaxis. Currently, two different reactivity patterns have been shown to initiate an immune reaction by activating T cells-the hapten concept and the pharmacological interaction with immune receptor (p-i) concept.