The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions.

Publikation

The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions.

Wissenschaftlicher Artikel/Review - 21.02.2022

Wuillemin Natascha, Ballmer-Weber Barbara, Schlapbach Christoph, Jörg Lukas, Yerly Daniel

Zitation

Wuillemin N, Ballmer-Weber B, Schlapbach C, Jörg L, Yerly D. The Activation Pattern of Drug-Reacting T Cells Has an Impact on the Clinical Picture of Hypersensitivity Reactions. Front Allergy 2022; 3:804605.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Front Allergy 2022; 3

Veröffentlichungsdatum

21.02.2022

eISSN (Online)

2673-6101

Seiten

804605

Kurzbeschreibung/Zielsetzung

β-lactam antibiotics cause drug hypersensitivity reactions (DHR) with various clinical pictures from minor affections like maculopapular exanthema (MPE) and urticaria to severe cutaneous adverse reactions and anaphylaxis. Currently, two different reactivity patterns have been shown to initiate an immune reaction by activating T cells-the hapten concept and the pharmacological interaction with immune receptor (p-i) concept.