The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation - Data from the Swiss transplant cohort study. - Publikation

Publikation

The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation - Data from the Swiss transplant cohort study.

Wissenschaftlicher Artikel/Review - 21.09.2022

Frischknecht Lukas, Deng Yun, Wehmeier Caroline, de Rougemont Olivier, Villard Jean, Ferrari-Lacraz Sylvie, Golshayan Déla, Gannagé Monique, Binet Isabelle, Wirthmueller Urs, Sidler Daniel, Schachtner Thomas, Schaub Stefan, Nilsson Jakob, Swiss Transplant Cohort Study

Zitation

Frischknecht L, Deng Y, Wehmeier C, de Rougemont O, Villard J, Ferrari-Lacraz S, Golshayan D, Gannagé M, Binet I, Wirthmueller U, Sidler D, Schachtner T, Schaub S, Nilsson J, Swiss Transplant Cohort Study. The impact of pre-transplant donor specific antibodies on the outcome of kidney transplantation - Data from the Swiss transplant cohort study. Front Immunol 2022; 13:1005790.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Front Immunol 2022; 13

Veröffentlichungsdatum

21.09.2022

eISSN (Online)

1664-3224

Seiten

1005790

Kurzbeschreibung/Zielsetzung

Pre-transplant donor specific antibodies (DSA), directed at non-self human leukocyte antigen (HLA) protein variants present in the donor organ, have been associated with worse outcomes in kidney transplantation. The impact of the mean fluorescence intensity (MFI) and the target HLA antigen of the detected DSA has, however, not been conclusively studied in a large cohort with a complete virtual cross-match (vXM).