Publikation

Biomarkers for the diagnosis of cognitive impairment

Recommendations from the Swiss Memory Clinics

Wissenschaftlicher Artikel/Review - 12.10.2022

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Zitation
Popp J, Georgescu D, Bürge M, Mundwiler-Pachatko E, Bernasconi L, Felbecker A. Biomarkers for the diagnosis of cognitive impairment - Recommendations from the Swiss Memory Clinics. Praxis 2022; 111:738-744.
Art
Wissenschaftlicher Artikel/Review (Deutsch)
Zeitschrift
Praxis 2022; 111
Veröffentlichungsdatum
12.10.2022
ISSN (Druck)
1661-8157
eISSN (Online)
1661-8165
Seiten
738-744
Verlag
Hogrefe Verlag (Bern)
Kurzbeschreibung/Zielsetzung

Biomarkers for the diagnosis of cognitive impairment - Recommendations from the Swiss Memory Clinics Abstract. Molecular cerebrospinal fluid (CSF) biomarkers of neurodegenerative diseases are now part of the established diagnostic tools for the clinical investigation of cognitive disorders in the elderly. Biomarkers allow for earlier and more accurate differential diagnosis, and are recommended by the Swiss Memory Clinics as an additional investigation based upon individual indication. Information and counselling are needed both before and after biomarker-supported diagnosis. The procedures for diagnostic lumbar punctures and pre-analytical sample handling should follow published recommendations. The results must be interpreted in the context of the other available history and assessment outcome. Thanks to recent research progress, blood-based biomarkers and other non-invasive markers are expected to become available for clinical practice in the near future. This trend will likely lead to a much broader utilisation of biomarkers and may accelerate the development of effective and individually tailored prevention and treatment approaches. This review article provides an overview over the current state of biomarkers and provides the recommendations of the Swiss Memory Clinics for their use in clinical practice.