Publikation

Mortality in Patients with Brainstem Cavernous Malformations

Wissenschaftlicher Artikel/Review - 16.06.2021

Bereiche
PubMed
DOI

Zitation
Velz J, Neidert M, Yang Y, Akeret K, Nakaji P, Regli L, Bozinov O. Mortality in Patients with Brainstem Cavernous Malformations. Cerebrovasc Dis 2021; 50:574-580.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Cerebrovasc Dis 2021; 50
Veröffentlichungsdatum
16.06.2021
eISSN (Online)
1421-9786
Seiten
574-580
Kurzbeschreibung/Zielsetzung

OBJECTIVE
Brainstem cavernous malformations (BSCM)-associated mortality has been reported up to 20% in patients managed conservatively, whereas postoperative mortality rates range from 0 to 1.9%. Our aim was to analyze the actual risk and causes of BSCM-associated mortality in patients managed conservatively and surgically based on our own patient cohort and a systematic literature review.

METHODS
Observational, retrospective single-center study encompassing all patients with BSCM that presented to our institution between 2006 and 2018. In addition, a systematic review was performed on all studies encompassing patients with BSCM managed conservatively and surgically.

RESULTS
Of 118 patients, 54 were treated conservatively (961.0 person years follow-up in total). No BSCM-associated mortality was observed in our conservatively as well as surgically managed patient cohort. Our systematic literature review and analysis revealed an overall BSCM-associated mortality rate of 2.3% (95% CI: 1.6-3.3) in 22 studies comprising 1,251 patients managed conservatively and of 1.3% (95% CI: 0.9-1.7) in 99 studies comprising 3,275 patients with BSCM treated surgically.

CONCLUSION
The BSCM-associated mortality rate in patients managed conservatively is almost as low as in patients treated surgically and much lower than in frequently cited reports, most probably due to the good selection nowadays in regard to surgery.