Publikation

Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature

Wissenschaftlicher Artikel/Review - 01.04.2005

Bereiche
PubMed
DOI

Zitation
Beltraminelli H, Lerch M, Arnold A, Bircher A, Haeusermann P. Acute generalized exanthematous pustulosis induced by the antifungal terbinafine: case report and review of the literature. The British journal of dermatology 2005; 152:780-3.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
The British journal of dermatology 2005; 152
Veröffentlichungsdatum
01.04.2005
ISSN (Druck)
0007-0963
Seiten
780-3
Kurzbeschreibung/Zielsetzung

Cutaneous drug reactions occur with a frequency of 1-8% and can be higher for certain classes of drugs. They can range from mild morbilliform eruptions to more severe forms such as drug-hypersensitivity syndrome, toxic epidermal necrolysis or anaphylaxis. Acute generalized exanthematous pustulosis (AGEP) is considered to be a clinical reaction pattern, which is induced in over 90% of the cases by systemic drugs. It is a rare presentation of an adverse drug reaction most frequently triggered by anti-infectious drugs. A high proportion of these cases have been attributed to aminopenicillins and macrolides. We report a terbinafine-induced AGEP in a 68-year-old male confirmed by lymphocyte stimulation in vitro, and review the published cases induced by antimycotic drugs with special emphasis on terbinafine-triggered cases.