Publikation

Arterial inflammation and atherosclerosis

Wissenschaftlicher Artikel/Review - 01.05.2002

Bereiche
PubMed

Zitation
Ludewig B, Zinkernagel R, Hengartner H. Arterial inflammation and atherosclerosis. Trends in cardiovascular medicine 2002; 12:154-9.
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Trends in cardiovascular medicine 2002; 12
Veröffentlichungsdatum
01.05.2002
ISSN (Druck)
1050-1738
Seiten
154-9
Kurzbeschreibung/Zielsetzung

Arterial inflammation is a significant component of atherosclerotic disease and it has been suggested that specific immune responses directed against autoantigens or pathogen-derived antigens presented in the vascular wall could initiate and/or maintain atherosclerotic processes. Atherogenic cofactors such as altered cholesterol metabolism may not only impact locally on inflammatory responses in atherosclerotic lesions, but may also alter general immune-responsiveness. The evidence to date suggests that the mutual chronic perpetuation of immune mediated vascular inflammation and cholesterol-induced atherosclerosis is a key step in atherogenesis.