Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
Wissenschaftlicher Artikel/Review - 15.03.2018
Bueno-de-Mesquita H Bas, Dorronsoro Miren, Sánchez María-José, Obón-Santacana Mireia, Lasheras Cristina, Olsen Karina Standahl, Brustad Magritt, Peeters Petra, Matullo Giuseppe, Panico Salvatore, Tumino Rosario, Agnoli Claudia, Chirlaque Maria-Dolores, Barricarte Aurelio, Riboli Elio, Norat Teresa, Aune Dagfinn, Freisling Heinz, Bradbury Kathryn E, Khaw Kay-Tee, Wareham Nick, Ye Weimin, Renström Frida, Almquist Martin, Manjer Jonas, Palli Domenico, Kritikou Maria, Murphy Neil, Weiderpass Elisabete, van den Ouweland Jody M W, van Kranen Henk J, Halfweeg Anouk, Kampman Ellen, Duell Eric J, Fedirko Veronika, Siersema Peter D, Hveem Kristian, Jenab Mazda, Langhammer Arnulf, Ness-Jensen Eivind, Kotanidou Anastasia, Trichopoulou Antonia, Boeing Heiner, Kühn Tilman, Katzke Verena A, Boutron-Ruault Marie-Christine, Kvaskoff Marina, Cadeau Claire, Overvad Kim, Tjønneland Anne, Olsen Anja, van Duijnhoven Fränzel J B
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.