Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
Journal Paper/Review - Mar 15, 2018
van Duijnhoven Fränzel J B, Jenab Mazda, Hveem Kristian, Siersema Peter D, Fedirko Veronika, Duell Eric J, Kampman Ellen, Halfweeg Anouk, van Kranen Henk J, van den Ouweland Jody M W, Weiderpass Elisabete, Murphy Neil, Langhammer Arnulf, Ness-Jensen Eivind, Olsen Anja, Tjønneland Anne, Overvad Kim, Cadeau Claire, Kvaskoff Marina, Boutron-Ruault Marie-Christine, Katzke Verena A, Kühn Tilman, Boeing Heiner, Trichopoulou Antonia, Kotanidou Anastasia, Kritikou Maria, Palli Domenico, Agnoli Claudia, Tumino Rosario, Panico Salvatore, Matullo Giuseppe, Peeters Petra, Brustad Magritt, Olsen Karina Standahl, Lasheras Cristina, Obón-Santacana Mireia, Sánchez María-José, Dorronsoro Miren, Chirlaque Maria-Dolores, Barricarte Aurelio, Manjer Jonas, Almquist Martin, Renström Frida, Ye Weimin, Wareham Nick, Khaw Kay-Tee, Bradbury Kathryn E, Freisling Heinz, Aune Dagfinn, Norat Teresa, Riboli Elio, Bueno-de-Mesquita H Bas
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.