Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

Publikation

Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

Wissenschaftlicher Artikel/Review - 29.04.2016

Scherrer Alexandra U, Günthard Huldrych F, Bernasconi Enos, Schmid Patrick, Calmy Alexandra, Hauser Christoph, Battegay Manuel, Cavassini Matthias, Aubert Vincent, Klimkait Thomas, Yerly Sabine, Böni Jürg, Kouyos Roger D, Yang Wan-Lin

Zitation

Scherrer A, Günthard H, Bernasconi E, Schmid P, Calmy A, Hauser C, Battegay M, Cavassini M, Aubert V, Klimkait T, Yerly S, Böni J, Kouyos R, Yang W. Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study. J Infect Dis 2016; 214:399-402.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

J Infect Dis 2016; 214

Veröffentlichungsdatum

29.04.2016

eISSN (Online)

1537-6613

Seiten

399-402

Kurzbeschreibung/Zielsetzung

The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.