Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

Publication

Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study

Journal Paper/Review - Apr 29, 2016

Scherrer Alexandra U, Günthard Huldrych F, Bernasconi Enos, Schmid Patrick, Calmy Alexandra, Hauser Christoph, Battegay Manuel, Cavassini Matthias, Aubert Vincent, Klimkait Thomas, Yerly Sabine, Böni Jürg, Kouyos Roger D, Yang Wan-Lin

Citation

Scherrer A, Günthard H, Bernasconi E, Schmid P, Calmy A, Hauser C, Battegay M, Cavassini M, Aubert V, Klimkait T, Yerly S, Böni J, Kouyos R, Yang W. Successful Prevention of Transmission of Integrase Resistance in the Swiss HIV Cohort Study. J Infect Dis 2016; 214:399-402.

Type

Journal Paper/Review (English)

Journal

J Infect Dis 2016; 214

Publication Date

Apr 29, 2016

Issn Electronic

1537-6613

Pages

399-402

Brief description/objective

The prevalence of integrase strand transfer inhibitor (INSTI)-transmitted drug resistance (TDR) may increase with the increasing use of INSTIs. We analyzed the prevalence of INSTI TDR in the Swiss HIV Cohort Study (2008-2014). In 1 of 1316 drug-naive samples (0.1%), a major INSTI TDR mutation was detected. Prevalence was stable, although INSTIs were increasingly used. We showed that this is in contrast to the introduction of previous drug classes, in which more treatment failures with resistant strains occurred and TDR was observed more rapidly. We demonstrated on a population-level that it is possible to avoid TDR to a new drug class for years.