Publikation
Harmlose blaue Flecken? Gerinnungsstörung trotz normaler INR
Wissenschaftlicher Artikel/Review - 23.07.2014
Greuter Ladina, Schöb Manuela, Lehmann Thomas, Diethelm Markus
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Kurzbeschreibung/Zielsetzung
Acquired hemophilia is a rare but severe bleeding disorder caused by autoantibodies mostly against factor VIII. Clinically it mostly presents with soft tissue and muscular bleeding. Diagnostics include a prolonged aPTT, antibodies against FVIII and a reduced FVIII titre. Acute bleeding is controlled with recombinant factor VIIa (NovoSeven(®)) or activated prothrombin complex (FEIBA(®)), as both bypass FVIII in the coagulation pathway. Treatment to reduce the inhibitor consists of immunosuppression with corticosteroids, cyclophosphamid and can be extended with rituximab.