Harmlose blaue Flecken? Gerinnungsstörung trotz normaler INR

Publication

Harmlose blaue Flecken? Gerinnungsstörung trotz normaler INR

Journal Paper/Review - Jul 23, 2014

Greuter Ladina, Schöb Manuela, Lehmann Thomas, Diethelm Markus

Citation

Greuter L, Schöb M, Lehmann T, Diethelm M. Harmlose blaue Flecken? Gerinnungsstörung trotz normaler INR. Praxis (Bern 1994) 2014; 103:899-902.

Type

Journal Paper/Review (English)

Journal

Praxis (Bern 1994) 2014; 103

Publication Date

Jul 23, 2014

Issn Print

1661-8157

Pages

899-902

Brief description/objective

Acquired hemophilia is a rare but severe bleeding disorder caused by autoantibodies mostly against factor VIII. Clinically it mostly presents with soft tissue and muscular bleeding. Diagnostics include a prolonged aPTT, antibodies against FVIII and a reduced FVIII titre. Acute bleeding is controlled with recombinant factor VIIa (NovoSeven(®)) or activated prothrombin complex (FEIBA(®)), as both bypass FVIII in the coagulation pathway. Treatment to reduce the inhibitor consists of immunosuppression with corticosteroids, cyclophosphamid and can be extended with rituximab.