Publication

Harmlose blaue Flecken? Gerinnungsstörung trotz normaler INR

Journal Paper/Review - Jul 23, 2014

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Citation
Greuter L, Schöb M, Lehmann T, Diethelm M. Harmlose blaue Flecken? Gerinnungsstörung trotz normaler INR. Praxis (Bern 1994) 2014; 103:899-902.
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Type
Journal Paper/Review (English)
Journal
Praxis (Bern 1994) 2014; 103
Publication Date
Jul 23, 2014
Issn Print
1661-8157
Issn Electronic
Pages
899-902
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Brief description/objective

Acquired hemophilia is a rare but severe bleeding disorder caused by autoantibodies mostly against factor VIII. Clinically it mostly presents with soft tissue and muscular bleeding. Diagnostics include a prolonged aPTT, antibodies against FVIII and a reduced FVIII titre. Acute bleeding is controlled with recombinant factor VIIa (NovoSeven(®)) or activated prothrombin complex (FEIBA(®)), as both bypass FVIII in the coagulation pathway. Treatment to reduce the inhibitor consists of immunosuppression with corticosteroids, cyclophosphamid and can be extended with rituximab.