A systems biologist's view on dendritic cell-cytotoxic T lymphocyte interaction

Publikation

A systems biologist's view on dendritic cell-cytotoxic T lymphocyte interaction

Buchkapitel - 01.01.2006

Ludewig Burkhard, Bocharov Gennady, Lutz Manfred, Romani Nikolaus, Steinkasserer Alexander

Bereiche

Medizinisches Forschungszentrum, Institut für Immunbiologie

Schlagwörter (Tags)

Dendritic Cells, T cells

Zitation

Ludewig B, Bocharov G, Lutz M, Romani N, Steinkasserer A. A systems biologist's view on dendritic cell-cytotoxic T lymphocyte interaction. In: Handbook of Dendritic Cells. Weinheim: Wiley-VCH, 2005. ISBN 978-3-527-31109-5. S. 455-480.

Art

Buchkapitel (Englisch)

Buchtitel

Handbook of Dendritic Cells

Veröffentlichungsdatum

01.01.2006

ISBN Nummer

978-3-527-31109-5

Seiten

455-480

Verlag

Wiley-VCH (Weinheim)

Kurzbeschreibung/Zielsetzung

The induction of protective CTL responses by DCs represents a robust biological system as it ensures protection of individuals against the vast majority of pathogens and helps to maintain immune surveillance of tumors. Novel vaccination approaches for the improvement of CTL responses against infectious agents and tumors should be based upon the systems biology analysis of the robustness of DC-CTL interaction as well as the fragility of the pathological steady states. The presented framework should help to provide parsimonious conceptualization of in vitro and in vivo observations to avoid unnecessary complexities (e.g. divergent DC subsets or intermediate maturation stages). Thus, structure, dynamics, design and control principles of DC-induced CTL responses represent important issues that require the attention of further research efforts.