A systems biologist's view on dendritic cell-cytotoxic T lymphocyte interaction

Publication

A systems biologist's view on dendritic cell-cytotoxic T lymphocyte interaction

Book Chapter - Jan 1, 2006

Ludewig Burkhard, Bocharov Gennady, Lutz Manfred, Romani Nikolaus, Steinkasserer Alexander

Units

Medizinisches Forschungszentrum, Institute of Immunobiology

Keywords

Dendritic Cells, T cells

Citation

Ludewig B, Bocharov G, Lutz M, Romani N, Steinkasserer A. A systems biologist's view on dendritic cell-cytotoxic T lymphocyte interaction. In: Handbook of Dendritic Cells. Weinheim: Wiley-VCH, 2006. ISBN 978-3-527-31109-5. pp. 455-480.

Type

Book Chapter (English)

Book Title

Handbook of Dendritic Cells

Publication Date

Jan 1, 2006

Isbn Number

978-3-527-31109-5

Pages

455-480

Publisher

Wiley-VCH (Weinheim)

Brief description/objective

The induction of protective CTL responses by DCs represents a robust biological system as it ensures protection of individuals against the vast majority of pathogens and helps to maintain immune surveillance of tumors. Novel vaccination approaches for the improvement of CTL responses against infectious agents and tumors should be based upon the systems biology analysis of the robustness of DC-CTL interaction as well as the fragility of the pathological steady states. The presented framework should help to provide parsimonious conceptualization of in vitro and in vivo observations to avoid unnecessary complexities (e.g. divergent DC subsets or intermediate maturation stages). Thus, structure, dynamics, design and control principles of DC-induced CTL responses represent important issues that require the attention of further research efforts.