Reactive macrophage activation syndrome: a simple screening strategy and its potential in early treatment initiation

Publikation

Reactive macrophage activation syndrome: a simple screening strategy and its potential in early treatment initiation

Wissenschaftlicher Artikel/Review - 04.05.2002

Emmenegger U, Spaeth P J, Cerny A, Cottagnoud P, Semela David, Bihl F, Fux Ch, Frey U, Reimers A, Neftel Klaus A

Zitation

Emmenegger U, Spaeth P, Cerny A, Cottagnoud P, Semela D, Bihl F, Fux C, Frey U, Reimers A, Neftel K. Reactive macrophage activation syndrome: a simple screening strategy and its potential in early treatment initiation. Swiss Med Wkly 2002; 132:230-6.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Swiss Med Wkly 2002; 132

Veröffentlichungsdatum

04.05.2002

ISSN (Druck)

1424-7860

Seiten

230-6

Kurzbeschreibung/Zielsetzung

starting treatment of reactive macrophage activation syndromes as early as possible (rMAS, haemophagocytic lymphohistiocytosis), e.g., with intravenous immunoglobulins (IVIG), seems to be essential for optimal outcome. However, there is no diagnostic gold standard which reliably indicates need for early treatment. We used a simple screening strategy consisting of serum ferritin measurements and/or morphological assessment of haemophagocytosis and compared the studied patient population with published series.