Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function

Publikation

Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function

Wissenschaftlicher Artikel/Review - 16.04.2008

Semela David, Das Amitava, Langer Daniel, Kang Ningling, Leof Edward, Shah Vijay

Zitation

Semela D, Das A, Langer D, Kang N, Leof E, Shah V. Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function. Gastroenterology 2008; 135:671-9.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Gastroenterology 2008; 135

Veröffentlichungsdatum

16.04.2008

eISSN (Online)

1528-0012

Seiten

671-9

Kurzbeschreibung/Zielsetzung

Cirrhosis is associated with prominent changes in sinusoidal structure and function. Although the resident pericyte in liver, the hepatic stellate cell (HSC), is well characterized in the process of fibrogenesis, signaling pathways that regulate HSC vascular function are less developed. Because pericyte populations outside the liver are increasingly being recognized as a key cell type for angiogenesis and changes in vascular structure, in this study, we explore new HSC-signaling pathways that regulate sinusoidal structure and function.