Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function

Publication

Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function

Journal Paper/Review - Apr 16, 2008

Semela David, Das Amitava, Langer Daniel, Kang Ningling, Leof Edward, Shah Vijay

Citation

Semela D, Das A, Langer D, Kang N, Leof E, Shah V. Platelet-derived growth factor signaling through ephrin-b2 regulates hepatic vascular structure and function. Gastroenterology 2008; 135:671-9.

Type

Journal Paper/Review (English)

Journal

Gastroenterology 2008; 135

Publication Date

Apr 16, 2008

Issn Electronic

1528-0012

Pages

671-9

Brief description/objective

Cirrhosis is associated with prominent changes in sinusoidal structure and function. Although the resident pericyte in liver, the hepatic stellate cell (HSC), is well characterized in the process of fibrogenesis, signaling pathways that regulate HSC vascular function are less developed. Because pericyte populations outside the liver are increasingly being recognized as a key cell type for angiogenesis and changes in vascular structure, in this study, we explore new HSC-signaling pathways that regulate sinusoidal structure and function.