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Randomized controlled study demonstrating failure of LPV/r monotherapy in HIV: the role of compartment and CD4-nadir
Wissenschaftlicher Artikel/Review - 24.09.2010
Gutmann Christine, Vernazza Pietro, Yerly Sabine, Cavassini Matthias, Decosterd Laurent-Arthur, Hirschel Bernard, Fux Christoph, Günthard Huldrych F, Cusini Alexia, Swiss HIV Cohort Study (SHCS)
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Long-term side-effects and cost of HIV treatment motivate the development of simplified maintenance. Monotherapy with ritonavir-boosted lopinavir (LPV/r-MT) is the most widely studied strategy. However, efficacy of LPV/r-MT in compartments remains to be shown.