Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

Publikation

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

Wissenschaftlicher Artikel/Review - 21.06.2004

van Swieten Paul F, Ploegh Hidde L, van der Marel Gijsbert A, Driessen Christoph, Leeuwenburgh Michiel A, Kalbacher Hubert, Wong Chung-Sing, Reich Michael, Kessler Benedikt M, van den Nieuwendijk Adrianus M C H, Maehr Rene, Overkleeft Herman S

Zitation

van Swieten P, Ploegh H, van der Marel G, Driessen C, Leeuwenburgh M, Kalbacher H, Wong C, Reich M, Kessler B, van den Nieuwendijk A, Maehr R, Overkleeft H. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorganic & medicinal chemistry letters 2004; 14:3131-4.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Bioorganic & medicinal chemistry letters 2004; 14

Veröffentlichungsdatum

21.06.2004

ISSN (Druck)

0960-894X

Seiten

3131-4

Kurzbeschreibung/Zielsetzung

Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins.