Publication

Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases

Journal Paper/Review - Jun 21, 2004

Units
PubMed
Doi

Citation
van Swieten P, Ploegh H, van der Marel G, Driessen C, Leeuwenburgh M, Kalbacher H, Wong C, Reich M, Kessler B, van den Nieuwendijk A, Maehr R, Overkleeft H. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorganic & medicinal chemistry letters 2004; 14:3131-4.
Type
Journal Paper/Review (English)
Journal
Bioorganic & medicinal chemistry letters 2004; 14
Publication Date
Jun 21, 2004
Issn Print
0960-894X
Pages
3131-4
Brief description/objective

Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins.