Publication
Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases
Journal Paper/Review - Jun 21, 2004
van Swieten Paul F, Ploegh Hidde L, van der Marel Gijsbert A, Driessen Christoph, Leeuwenburgh Michiel A, Kalbacher Hubert, Wong Chung-Sing, Reich Michael, Kessler Benedikt M, van den Nieuwendijk Adrianus M C H, Maehr Rene, Overkleeft Herman S
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PubMed
Doi
Citation
Type
Journal
Publication Date
Issn Print
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Brief description/objective
Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins.