Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole

Publikation

Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole

Wissenschaftlicher Artikel/Review - 01.01.2007

Krauss K, Bachmann C, Hartmann J T, Siegmann K, Sotlar K, Wallwiener D, Huober Jens

Zitation

Krauss K, Bachmann C, Hartmann J, Siegmann K, Sotlar K, Wallwiener D, Huober J. Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole. Anticancer research 2007; 27:3477-80.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Anticancer research 2007; 27

Veröffentlichungsdatum

01.01.2007

ISSN (Druck)

0250-7005

Seiten

3477-80

Kurzbeschreibung/Zielsetzung

Low grade endometrial stromal sarcoma (LGESS) is a rare disease. LGESS usually expresses steroidal receptors and is regarded to be hormone-sensitive. Due to the rarity of the tumor, only few case series have been published so far. Here, we report the case of a 36-year-old woman who underwent an abdominal hysterectomy with bilateral salpingo-oophorectomy and adjuvant radiotherapy for a G1 LGESS in 1991. Twelve years later she presented to us with pelvic and peritoneal masses. The patient was treated with letrozole achieving a partial response which is lasting 39 months. Treatment is ongoing. Aromatase inhibitors represent an interesting treatment option for LGESS.