Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole

Publication

Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole

Journal Paper/Review - Jan 1, 2007

Krauss K, Bachmann C, Hartmann J T, Siegmann K, Sotlar K, Wallwiener D, Huober Jens

Citation

Krauss K, Bachmann C, Hartmann J, Siegmann K, Sotlar K, Wallwiener D, Huober J. Management of late recurrence of a low-grade endometrial stromal sarcoma (LGESS): treatment with letrozole. Anticancer research 2007; 27:3477-80.

Type

Journal Paper/Review (English)

Journal

Anticancer research 2007; 27

Publication Date

Jan 1, 2007

Issn Print

0250-7005

Pages

3477-80

Brief description/objective

Low grade endometrial stromal sarcoma (LGESS) is a rare disease. LGESS usually expresses steroidal receptors and is regarded to be hormone-sensitive. Due to the rarity of the tumor, only few case series have been published so far. Here, we report the case of a 36-year-old woman who underwent an abdominal hysterectomy with bilateral salpingo-oophorectomy and adjuvant radiotherapy for a G1 LGESS in 1991. Twelve years later she presented to us with pelvic and peritoneal masses. The patient was treated with letrozole achieving a partial response which is lasting 39 months. Treatment is ongoing. Aromatase inhibitors represent an interesting treatment option for LGESS.