How transgenic mouse models contribute to a better understanding of virus-induced autoimmunity

Publikation

How transgenic mouse models contribute to a better understanding of virus-induced autoimmunity

Buchkapitel - 01.01.2004

Ludewig Burkhard, Krebs Philippe, Rose Noel, Shoenfeld Yehuda

Bereiche

Medizinisches Forschungszentrum, Institut für Immunbiologie

Schlagwörter (Tags)

Autoimmunity, T cells

Zitation

Ludewig B, Krebs P, Rose N, Shoenfeld Y. How transgenic mouse models contribute to a better understanding of virus-induced autoimmunity. In: Infection and Autoimmunity. Elsevier Science, 2004. ISBN 978-0444512710. S. 155-162.

Art

Buchkapitel (Englisch)

Buchtitel

Infection and Autoimmunity

Veröffentlichungsdatum

01.01.2004

Titel der Reihe

Infection and Autoimmunity ()

ISBN Nummer

978-0444512710

Seiten

155-162

Verlag

Elsevier Science

Kurzbeschreibung/Zielsetzung

Viruses may disturb the fine-tuned balance of the immune system by acting as "adjuvant" and/or by stimulating cross-reactive T and B cells with specifity for both viral and self antigens. Transgenic mouse models have helped to uncover the basic rules how virus interfere with self tolerance. Furthermore, the different transgenic mouse models of virus-induced autoimmunity described here represent valuable tools to delineate basic pathogenic mechanisms and to evaluate therapeutical strategies to intervene with early detrimental processes that lead to manifest autoimmune disease.