How transgenic mouse models contribute to a better understanding of virus-induced autoimmunity

Publication

How transgenic mouse models contribute to a better understanding of virus-induced autoimmunity

Book Chapter - Jan 1, 2004

Ludewig Burkhard, Krebs Philippe, Rose Noel, Shoenfeld Yehuda

Units

Medizinisches Forschungszentrum, Institute of Immunobiology

Keywords

Autoimmunity, T cells

Citation

Ludewig B, Krebs P, Rose N, Shoenfeld Y. How transgenic mouse models contribute to a better understanding of virus-induced autoimmunity. In: Infection and Autoimmunity. Elsevier Science, 2004. ISBN 978-0444512710. pp. 155-162.

Type

Book Chapter (English)

Book Title

Infection and Autoimmunity

Publication Date

Jan 1, 2004

Series Title

Infection and Autoimmunity ()

Isbn Number

978-0444512710

Pages

155-162

Publisher

Elsevier Science

Brief description/objective

Viruses may disturb the fine-tuned balance of the immune system by acting as "adjuvant" and/or by stimulating cross-reactive T and B cells with specifity for both viral and self antigens. Transgenic mouse models have helped to uncover the basic rules how virus interfere with self tolerance. Furthermore, the different transgenic mouse models of virus-induced autoimmunity described here represent valuable tools to delineate basic pathogenic mechanisms and to evaluate therapeutical strategies to intervene with early detrimental processes that lead to manifest autoimmune disease.