A single-nucleotide polymorphism in the sterol-regulatory element-binding protein 1c gene is predictive of HIV-related hyperlipoproteinaemia

Publikation

A single-nucleotide polymorphism in the sterol-regulatory element-binding protein 1c gene is predictive of HIV-related hyperlipoproteinaemia

Wissenschaftlicher Artikel/Review - 19.10.2001

Miserez A R, Muller P Y, Barella L, Schwietert M, Erb P, Vernazza Pietro, Battegay M, Swiss HIV Cohort Study

Bereiche

Infektiologie | Infektionsprävention | Reisemedizin

PubMed

11600836

Zitation

Miserez A, Muller P, Barella L, Schwietert M, Erb P, Vernazza P, Battegay M, Swiss HIV Cohort Study. A single-nucleotide polymorphism in the sterol-regulatory element-binding protein 1c gene is predictive of HIV-related hyperlipoproteinaemia. AIDS (London, England) 2001; 15:2045-9.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

AIDS (London, England) 2001; 15

Veröffentlichungsdatum

19.10.2001

ISSN (Druck)

0269-9370

Seiten

2045-9

Kurzbeschreibung/Zielsetzung

A single-nucleotide polymorphism (3'322C/G) was identified in the gene encoding a key cholesterol/triglyceride regulator, sterol-regulatory element-binding protein 1c (SREBP-1c). Although it did not alter the amino acid sequence, SREBP-1c-3'322C/G was predictive of highly active antiretroviral therapy-related hyperlipoproteinaemia. Increases in cholesterol were less frequently associated with homozygous SREBP-1c-3'322G (genotype 22) than with heterozygous/homozygous SREBP-1c-3'322C (genotypes 11/12) and correlated with leptin and insulin increases, particularly in genotype 11/12 carriers. A functional mutation linked to SREBP-1c-3'322C/G or messenger RNA conformation differences may explain our findings.