A single-nucleotide polymorphism in the sterol-regulatory element-binding protein 1c gene is predictive of HIV-related hyperlipoproteinaemia

Publication

A single-nucleotide polymorphism in the sterol-regulatory element-binding protein 1c gene is predictive of HIV-related hyperlipoproteinaemia

Journal Paper/Review - Oct 19, 2001

Miserez A R, Muller P Y, Barella L, Schwietert M, Erb P, Vernazza Pietro, Battegay M, Swiss HIV Cohort Study

Units

Division of Infectious Diseases, Infection Prevention and Travel Medicine

PubMed

11600836

Citation

Miserez A, Muller P, Barella L, Schwietert M, Erb P, Vernazza P, Battegay M, Swiss HIV Cohort Study. A single-nucleotide polymorphism in the sterol-regulatory element-binding protein 1c gene is predictive of HIV-related hyperlipoproteinaemia. AIDS (London, England) 2001; 15:2045-9.

Type

Journal Paper/Review (English)

Journal

AIDS (London, England) 2001; 15

Publication Date

Oct 19, 2001

Issn Print

0269-9370

Pages

2045-9

Brief description/objective

A single-nucleotide polymorphism (3'322C/G) was identified in the gene encoding a key cholesterol/triglyceride regulator, sterol-regulatory element-binding protein 1c (SREBP-1c). Although it did not alter the amino acid sequence, SREBP-1c-3'322C/G was predictive of highly active antiretroviral therapy-related hyperlipoproteinaemia. Increases in cholesterol were less frequently associated with homozygous SREBP-1c-3'322G (genotype 22) than with heterozygous/homozygous SREBP-1c-3'322C (genotypes 11/12) and correlated with leptin and insulin increases, particularly in genotype 11/12 carriers. A functional mutation linked to SREBP-1c-3'322C/G or messenger RNA conformation differences may explain our findings.