Publikation

Systematic Review of In Vivo Animal Models of Subarachnoid Hemorrhage: Species, Standard Parameters, and Outcomes.

Wissenschaftlicher Artikel/Review - 12.09.2018

Bereiche
PubMed
DOI
Kontakt

Zitation
Marbacher S, Grüter B, Schöpf S, Croci D, Nevzati E, D'Alonzo D, Lattmann J, Roth T, Bircher B, Wolfert C, Muroi C, Dutilh G, Widmer H, Fandino J. Systematic Review of In Vivo Animal Models of Subarachnoid Hemorrhage: Species, Standard Parameters, and Outcomes. Transl Stroke Res 2018
Art
Wissenschaftlicher Artikel/Review (Englisch)
Zeitschrift
Transl Stroke Res 2018
Veröffentlichungsdatum
12.09.2018
eISSN (Online)
1868-601X
Kurzbeschreibung/Zielsetzung

In preclinical models, modification of experimental parameters associated with techniques of inducing subarachnoid hemorrhage (SAH) can greatly affect outcomes. To analyze how parameter choice affects the relevance and comparability of findings, we systematically reviewed 765 experimental studies of in vivo animal SAH models (2000-2014). During the last decade, we found marked increases in publications using smaller species and models for simulating acute events after SAH. Overall, the fewer types of species and models used did not correlate with an increased standardization in the experimental characteristics and procedures. However, by species, commonly applied, reliable parameters for each experimental SAH technique were identified in mouse, rat, rabbit, and dog models. Our findings can serve as a starting point for discussion toward a more uniform performance of SAH experiments, development of preclinical SAH common data elements, and establishment of standardized protocols for multicenter preclinical trials.