Publication
Systematic Review of In Vivo Animal Models of Subarachnoid Hemorrhage: Species, Standard Parameters, and Outcomes.
Journal Paper/Review - Sep 12, 2018
Marbacher Serge, Grüter Basil, Schöpf Salome, Croci Davide Marco, Nevzati Edin, D'Alonzo Donato, Lattmann Jacqueline, Roth Tabitha, Bircher Benjamin, Wolfert Christina, Muroi Carl I, Dutilh Gilles, Widmer Hans Rudolf, Fandino Javier
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PubMed
Doi
Contact
Citation
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Journal
Publication Date
Issn Electronic
Brief description/objective
In preclinical models, modification of experimental parameters associated with techniques of inducing subarachnoid hemorrhage (SAH) can greatly affect outcomes. To analyze how parameter choice affects the relevance and comparability of findings, we systematically reviewed 765 experimental studies of in vivo animal SAH models (2000-2014). During the last decade, we found marked increases in publications using smaller species and models for simulating acute events after SAH. Overall, the fewer types of species and models used did not correlate with an increased standardization in the experimental characteristics and procedures. However, by species, commonly applied, reliable parameters for each experimental SAH technique were identified in mouse, rat, rabbit, and dog models. Our findings can serve as a starting point for discussion toward a more uniform performance of SAH experiments, development of preclinical SAH common data elements, and establishment of standardized protocols for multicenter preclinical trials.