Disbalanced recruitment of crossed and uncrossed cerebello-thalamic pathways during deep brain stimulation is predictive of delayed therapy escape in essential tremor.

Publikation

Disbalanced recruitment of crossed and uncrossed cerebello-thalamic pathways during deep brain stimulation is predictive of delayed therapy escape in essential tremor.

Wissenschaftlicher Artikel/Review - 12.02.2024

Sajonz Bastian Elmar Alexander, Frommer Marvin L, Reisert Marco, Blazhenets Ganna, Schröter Nils, Rau Alexander, Prokop Thomas, Reinacher Peter C, Rijntjes Michel, Urbach Horst, Meyer Philipp T, Coenen Volker Arnd

Zitation

Sajonz B, Frommer M, Reisert M, Blazhenets G, Schröter N, Rau A, Prokop T, Reinacher P, Rijntjes M, Urbach H, Meyer P, Coenen V. Disbalanced recruitment of crossed and uncrossed cerebello-thalamic pathways during deep brain stimulation is predictive of delayed therapy escape in essential tremor. Neuroimage Clin 2024; 41:103576.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Neuroimage Clin 2024; 41

Veröffentlichungsdatum

12.02.2024

eISSN (Online)

2213-1582

Seiten

103576

Kurzbeschreibung/Zielsetzung

Thalamic deep brain stimulation (DBS) is an efficacious treatment for drug-resistant essential tremor (ET) and the dentato-rubro-thalamic tract (DRT) constitutes an important target structure. However, up to 40% of patients habituate and lose treatment efficacy over time, frequently accompanied by a stimulation-induced cerebellar syndrome. The phenomenon termed delayed therapy escape (DTE) is insufficiently understood. Our previous work showed that DTE clinically is pronounced on the non-dominant side and suggested that differential involvement of crossed versus uncrossed DRT (DRTx/DRTu) might play a role in DTE development.