Disbalanced recruitment of crossed and uncrossed cerebello-thalamic pathways during deep brain stimulation is predictive of delayed therapy escape in essential tremor.

Publication

Disbalanced recruitment of crossed and uncrossed cerebello-thalamic pathways during deep brain stimulation is predictive of delayed therapy escape in essential tremor.

Journal Paper/Review - Feb 12, 2024

Sajonz Bastian Elmar Alexander, Frommer Marvin L, Reisert Marco, Blazhenets Ganna, Schröter Nils, Rau Alexander, Prokop Thomas, Reinacher Peter C, Rijntjes Michel, Urbach Horst, Meyer Philipp T, Coenen Volker Arnd

Citation

Sajonz B, Frommer M, Reisert M, Blazhenets G, Schröter N, Rau A, Prokop T, Reinacher P, Rijntjes M, Urbach H, Meyer P, Coenen V. Disbalanced recruitment of crossed and uncrossed cerebello-thalamic pathways during deep brain stimulation is predictive of delayed therapy escape in essential tremor. Neuroimage Clin 2024; 41:103576.

Type

Journal Paper/Review (English)

Journal

Neuroimage Clin 2024; 41

Publication Date

Feb 12, 2024

Issn Electronic

2213-1582

Pages

103576

Brief description/objective

Thalamic deep brain stimulation (DBS) is an efficacious treatment for drug-resistant essential tremor (ET) and the dentato-rubro-thalamic tract (DRT) constitutes an important target structure. However, up to 40% of patients habituate and lose treatment efficacy over time, frequently accompanied by a stimulation-induced cerebellar syndrome. The phenomenon termed delayed therapy escape (DTE) is insufficiently understood. Our previous work showed that DTE clinically is pronounced on the non-dominant side and suggested that differential involvement of crossed versus uncrossed DRT (DRTx/DRTu) might play a role in DTE development.