Is personal physiology-based rapid prediction digital twin for minimal effective fentanyl dose better than standard practice: a pilot study protocol.

Publikation

Is personal physiology-based rapid prediction digital twin for minimal effective fentanyl dose better than standard practice: a pilot study protocol.

Wissenschaftlicher Artikel/Review - 24.09.2024

Cukic Milena, Annaheim Simon, Bahrami Flora, Defraeye Thijs, De Nys Katelijne, Jörger Markus

Zitation

Cukic M, Annaheim S, Bahrami F, Defraeye T, De Nys K, Jörger M. Is personal physiology-based rapid prediction digital twin for minimal effective fentanyl dose better than standard practice: a pilot study protocol. BMJ Open 2024; 14:e085296.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

BMJ Open 2024; 14

Veröffentlichungsdatum

24.09.2024

eISSN (Online)

2044-6055

Seiten

e085296

Kurzbeschreibung/Zielsetzung

Patients with advanced cancer frequently suffer from chronic, severe disabling pain. Opioids such as morphine and fentanyl are commonly used to manage this pain. Transdermal drug delivery systems are important technologies for administering drugs in a non-invasive, continuous and controlled manner. Due to the narrow therapeutic range of fentanyl, individualised dosing is essential to avoid underdosing or overdosing. Standard clinical calculation tools for opioid rotation however do not include important patient characteristics that account for interindividual variability of opioid pharmacology.