Publication
Is personal physiology-based rapid prediction digital twin for minimal effective fentanyl dose better than standard practice: a pilot study protocol.
Journal Paper/Review - Sep 24, 2024
Cukic Milena, Annaheim Simon, Bahrami Flora, Defraeye Thijs, De Nys Katelijne, Jörger Markus
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PubMed
Doi
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Citation
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Journal
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Issn Electronic
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Brief description/objective
Patients with advanced cancer frequently suffer from chronic, severe disabling pain. Opioids such as morphine and fentanyl are commonly used to manage this pain. Transdermal drug delivery systems are important technologies for administering drugs in a non-invasive, continuous and controlled manner. Due to the narrow therapeutic range of fentanyl, individualised dosing is essential to avoid underdosing or overdosing. Standard clinical calculation tools for opioid rotation however do not include important patient characteristics that account for interindividual variability of opioid pharmacology.