Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course.

Publikation

Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course.

Wissenschaftlicher Artikel/Review - 21.06.2024

Akhoundova Dilara, Fischer Stefanie, Triscott Joanna, Lehner Marika, Thienger Phillip, Maletti Sina, Jacquet Muriel, Lubis Dinda S H, Bubendorf Lukas, Jochum Wolfram, Rubin Monika Afzali

Zitation

Akhoundova D, Fischer S, Triscott J, Lehner M, Thienger P, Maletti S, Jacquet M, Lubis D, Bubendorf L, Jochum W, Rubin M. Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course. Diagn Pathol 2024; 19:83.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Diagn Pathol 2024; 19

Veröffentlichungsdatum

21.06.2024

eISSN (Online)

1746-1596

Seiten

Kurzbeschreibung/Zielsetzung

Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations lead to overexpression of β-catenin, with consequent hyperactivation of the Wnt/β-catenin signaling pathway, implicated in PCa progression and treatment resistance. To date, successful targeted treatment options for Wnt/β-catenin - driven PCa are lacking.