Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course.

Publication

Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course.

Journal Paper/Review - Jun 21, 2024

Akhoundova Dilara, Fischer Stefanie, Triscott Joanna, Lehner Marika, Thienger Phillip, Maletti Sina, Jacquet Muriel, Lubis Dinda S H, Bubendorf Lukas, Jochum Wolfram, Rubin Monika Afzali

Citation

Akhoundova D, Fischer S, Triscott J, Lehner M, Thienger P, Maletti S, Jacquet M, Lubis D, Bubendorf L, Jochum W, Rubin M. Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course. Diagn Pathol 2024; 19:83.

Type

Journal Paper/Review (English)

Journal

Diagn Pathol 2024; 19

Publication Date

Jun 21, 2024

Issn Electronic

1746-1596

Brief description/objective

Catenin (Cadherin-Associated Protein), Beta 1 (CTNNB1) genomic alterations are rare in prostate cancer (PCa). Gain-of-function mutations lead to overexpression of β-catenin, with consequent hyperactivation of the Wnt/β-catenin signaling pathway, implicated in PCa progression and treatment resistance. To date, successful targeted treatment options for Wnt/β-catenin - driven PCa are lacking.