Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase 2b Trial.

Publikation

Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase 2b Trial.

Wissenschaftlicher Artikel/Review - 08.11.2023

Wildiers Hans, Armstrong Anne, Cuypere Eveline, Dalenc Florence, Dirix Luc, Chan Stephen, Marme Frederik, Schröder Carolina P, Huober Jens, Duhoux Francois P, Vuylsteke Peter, Jager Agnes, Brain Etienne, Kümmel Sherko, Pápai Zsuzsanna, Menke-van der Houven van Oordt Catharina Willemien, Perjesi Luca, Mueller Arndt-Christian, Brignone Chrystelle, Triebel Frederic

Zitation

Wildiers H, Armstrong A, Cuypere E, Dalenc F, Dirix L, Chan S, Marme F, Schröder C, Huober J, Duhoux F, Vuylsteke P, Jager A, Brain E, Kümmel S, Pápai Z, Menke-van der Houven van Oordt C, Perjesi L, Mueller A, Brignone C, Triebel F. Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase 2b Trial. Clin Cancer Res 2023

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Clin Cancer Res 2023

Veröffentlichungsdatum

08.11.2023

eISSN (Online)

1557-3265

Kurzbeschreibung/Zielsetzung

Eftilagimod alpha (efti), a soluble LAG-3 protein and MHC class II agonist, enhances innate and adaptive immunity. AIPAC evaluated safety and efficacy of efti plus paclitaxel in patients with predominantly endocrine-resistant, hormone receptor-positive, HER2-negative metastatic breast cancer (ET-resistant HR+ HER2- MBC).