Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase 2b Trial.

Publication

Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase 2b Trial.

Journal Paper/Review - Nov 8, 2023

Wildiers Hans, Armstrong Anne, Cuypere Eveline, Dalenc Florence, Dirix Luc, Chan Stephen, Marme Frederik, Schröder Carolina P, Huober Jens, Duhoux Francois P, Vuylsteke Peter, Jager Agnes, Brain Etienne, Kümmel Sherko, Pápai Zsuzsanna, Menke-van der Houven van Oordt Catharina Willemien, Perjesi Luca, Mueller Arndt-Christian, Brignone Chrystelle, Triebel Frederic

Citation

Wildiers H, Armstrong A, Cuypere E, Dalenc F, Dirix L, Chan S, Marme F, Schröder C, Huober J, Duhoux F, Vuylsteke P, Jager A, Brain E, Kümmel S, Pápai Z, Menke-van der Houven van Oordt C, Perjesi L, Mueller A, Brignone C, Triebel F. Paclitaxel plus Eftilagimod Alpha, a Soluble LAG-3 Protein, in Metastatic, HR+ Breast Cancer: Results from AIPAC, a Randomized, Placebo Controlled Phase 2b Trial. Clin Cancer Res 2023

Type

Journal Paper/Review (English)

Journal

Clin Cancer Res 2023

Publication Date

Nov 8, 2023

Issn Electronic

1557-3265

Brief description/objective

Eftilagimod alpha (efti), a soluble LAG-3 protein and MHC class II agonist, enhances innate and adaptive immunity. AIPAC evaluated safety and efficacy of efti plus paclitaxel in patients with predominantly endocrine-resistant, hormone receptor-positive, HER2-negative metastatic breast cancer (ET-resistant HR+ HER2- MBC).