Acidosis and alkali therapy in patients with kidney transplant is associated with transcriptional changes and altered abundance of genes involved in cell metabolism and acid-base balance.

Publikation

Acidosis and alkali therapy in patients with kidney transplant is associated with transcriptional changes and altered abundance of genes involved in cell metabolism and acid-base balance.

Wissenschaftlicher Artikel/Review - 27.09.2021

Imenez Silva Pedro H, Wiegand Anna, Daryadel Arezoo, Russo Giancarlo, Ritter Alexander, Gaspert Ariana, Wüthrich Rudolf P, Wagner Carsten A, Mohebbi Nilufar

Zitation

Imenez Silva P, Wiegand A, Daryadel A, Russo G, Ritter A, Gaspert A, Wüthrich R, Wagner C, Mohebbi N. Acidosis and alkali therapy in patients with kidney transplant is associated with transcriptional changes and altered abundance of genes involved in cell metabolism and acid-base balance. Nephrol Dial Transplant 2021; 36:1806-1820.

Art

Wissenschaftlicher Artikel/Review (Englisch)

Zeitschrift

Nephrol Dial Transplant 2021; 36

Veröffentlichungsdatum

27.09.2021

eISSN (Online)

1460-2385

Seiten

1806-1820

Kurzbeschreibung/Zielsetzung

Metabolic acidosis occurs frequently in patients with kidney transplant and is associated with a higher risk for and accelerated loss of graft function. To date, it is not known whether alkali therapy in these patients improves kidney function and whether acidosis and its therapy are associated with altered expression of proteins involved in renal acid-base metabolism.